Introduction
The idea behind this website was to create a central place that combines information,
tips and code (templates) for anything related to population PKPD modeling, focussing on NONMEM.
A lot of information is available however, it is scattered over the internet.
A lot of time is spend finding the right information.
Also, little information is available for people starting out with NONMEM analysis.
Additionally, useful code templates and code snippets will be placed on the website,
which can be directly copied and pasted into the users analysis.
NONMEM
NONMEM (Nonlinear Mixed Effects Modeling) is software used for fitting pharmacokinetic models.
(NONMEM).
Information concerning NONMEM, creating a NONMEM database and creating model files can be found under the tab NONMEM.
R
R is a free program for statistical analysis computing and graphics. R is very useful when working with (large) databases.
NONMEN with Pirana and PsN can be directly used with R to visualize the data and models.
(R-project website).
Actions can be automated by writing R scripts to speed up the repetitive processes in PK analysis.
NONMEM, R and PsN can be directly initialized via
Pirana.
Information and codes for using R in PK analysis can be found under the tab 'R'.
This website is a work in progess and will be regularly updated.
Recent updates:
- 27-Nov-2024: NONMEM code snippets, random and T and AUC above MIC code
- 06-Nov-2024: Changed code for Cmax and Tmax to $DES block
- 09-Sep-2022: I added a QUIZ to visualize the effect of changing PK parameters
- 01-Sep-2022: Added R code snippets, common nonmem errors.
- 21-Apr-2022: Added additional covariate methods.
- 10-Sep-2021: Changed confidence interval using standard error.
- 05-Aug-2021: Clarification some code snippets. Additional instructions.
- 05-May-2021: Added link to Data checker. Small errors fixed.
- 15-Jan-2021: Updated confidence interval calculation. Added label text scripts.
- 02-Nov-2020: Site structure changed, added code snippets R.
- 23-Sep-2020: Structure changed, added code snippets nonmem and R. Expanded NM datasets page.
- 20-Sep-2020: Added xpose4 documentation, changed code snippets.
- 17-Jul-2020: List of useful literature.
- 07-Jul-2020: 3D plots in R added, changed SCM code.
- 23-Jun-2020: Pirana scritps added, calculation page added, new nonmem code snippets