+--------------------------------------------------------------------+
| |
| SIZES FSIZES PRSIZES |
| |
+--------------------------------------------------------------------+
MEANING: MODULE for NONMEM and its components.
CONTEXT: Source code
DISCUSSION:
File SIZES is supplied on the NONMEM distribution media and is copied
to the resources directory. It contains FORTRAN PARAMETER statements
giving the default values of symbolic parameters used in source code.
Constants from SIZES may be incorporated into the source code by means
of the FORTRAN USE statement. Some of these constants describe array
sizes.
With NONMEM 7.2 and higher, there are several changes vs. previous
releases.
There is only one version of SIZES (i.e., there is no longer a
SIZES_reg or SIZES_big).
Many NONMEM and NM-TRAN arrays are allocated dynamically at run
time.
NM-TRAN creates a subroutine FSIZESR for NONMEM. FSIZESR con- |
tains values for some parameters (e.g., LVR) that are exactly |
what is needed for the current problem, and contains 0's for |
parameters that NM-TRAN cannot assess. Default values for param- |
eters that are 0 in FSIZESR are obtained by NONMEM from the file |
SIZES.f90. |
Note that file FSIZES is a convenient reference for users to |
view, but is not used. SUBROUTINE FSIZESR in FSUBS is what is |
actually used during the NONMEM run.
NM-TRAN creates a file prsizes.f90 for PREDPP. PREDPP arrays are
allocated statically but may be re-compiled at run time using
parameters defined in prsizes.f90. Some constants in prsizes are
assessed for the current problem; others are copied from default
values in SIZES.f90.
The user may override many of the parameter values in FSIZES and
prsizes with the $SIZES record. Any value specified by $SIZES
will override both the default in SIZES.f90 and the value that
NM-TRAN would have specified.
(See $sizes)
As of NONMEM 7.3, NMTRAN determines the maximum number of obser- |
vation records (MDV=0) that occur in any subject, among all data |
files used in the entire control stream file. If this value is |
greater than the NO value listed in SIZES.f90, it will set NO to |
this larger size. Thus, users no longer have to be conscientious |
of sizing the NO parameter. However, there is no guarantee that |
NMTRAN will correctly assess NO for the entire scope of the con- |
trol stream file for all types of problems. Should this occur, |
NONMEM may issue an error, and the user will need to set the NO |
value with a $SIZES record.
Constants that may be changed with $SIZES record:
LTH LVR LVR2 LPAR MMX MAXIDS NO PD MAXOMEG MAXPTHETA
Consants that are also in prsizes:
PC PCT PIR PD PAL MAXFCN
Constants that may not be changed using $SIZES record
LSTEXT MAXXNAME MAXVRESWRES MAXVRESN MXNAME DIMQ PPR PW SD SCO SDF
MAX_EXTRA
The following is the descriptive comment and value of each parameter
in the version of SIZES that is supplied on the NONMEM 7 distribution
medium. More information including descriptions of the buffers may be
found in the INTRODUCTION TO NONMEM 7.
NLUSER=100
Maximum number of logical I/O units user may use.
LTH=100
MAX. NO. OF THETA'S. Dynamically sized, or set by user via
$SIZES record
LVR=30
MAX. NO. OF ETA'S + EPS'S. Dynamically sized, or set by user via
$SIZES record
LVR2=20
MAX. NO. OF ETA'S PERMITTED WHEN LAPLACIAN METHOD IS USED. Value
may be over-ridden by user via $SIZES record
NO=250
MAX NO. OF OBSERVATION RECORDS / INDIVIDUAL RECORD
MMX=10
MAX NO. OF MIXTURE SUBPOPULATIONS. Dynamically sized, or set by
user via $SIZES record
LNP4=4000
SIZE OF COMMON NMPRD4. Value may be over-ridden by user via
$SIZES record
LSUPP=4050
MAX. NO. OF POINTS OF SUPPORT WITH NONPARAMETRIC ESTIMATE. Value
may be over-ridden by user via $SIZES record
LIM7=2
SIZE OF BUFFER 7. DO NOT GO LOWER THAN 2. Value may be over-
ridden by user via $SIZES record
LWS3=9000
SIZE OF WORKING SPACE 3 AT LEAST AS LARGE AS: NS*NOETAS**2, WHERE
NS IS THE NO. OF DIRECTIONS USED WITH THE STIELTJES METHOD, AND
NOETAS IS THE NUMBER OF ETA'S. Value may be over-ridden by user
via $SIZES record
MAXIDS=10000
MAX. NO. OF INDIVIDUALS IN DATA SET. Dynamically sized, or set
by user via $SIZES record
LIM1=10000
SIZE OF BUFFER 1. Value may be over-ridden by user via $SIZES
record
LIM2=100000
SIZE OF BUFFER 2. Value may be over-ridden by user via $SIZES
record
LIM3=10000
SIZE OF BUFFER 3. DO NOT GO LOWER THAN 2. Value may be over-rid-
den by user via $SIZES record
LIM4=1000
SIZE OF BUFFER 4: LIM4=NUMBER OF SUBJECTS. Value may be over-
ridden by user via $SIZES record
LIM5=200
SIZE OF BUFFER 5. Value may be over-ridden by user via $SIZES
record
LIM6=400
SIZE OF BUFFER 6. Value may be over-ridden by user via $SIZES
record
LIM8=200
SIZE OF BUFFER 8. Value may be over-ridden by user via $SIZES
record
LIM10=100000
SIZE OF BUFFER 10. Value may be over-ridden by user via $SIZES
record
LIM11=25
SIZE OF BUFFER 11. Value may be over-ridden by user via $SIZES
record
LIM13=1000
SIZE OF BUFFER 13: LIM13=NUMBER OF SUBJECTS. Value may be over-
ridden by user via $SIZES record
LIM15=1000
SIZE OF BUFFER 15: LIM15=NUMBER OF SUBJECTS. Value may be over-
ridden by user via $SIZES record
LIM16=400
SIZE OF BUFFER 16. Value may be over-ridden by user via $SIZES
record
LSTEXT=70000
AT LEAST (MAXOMEG*(MAXOMEG+1)/2+MAXPHETA+5)*NUMTEXT. LSTEXT is
maximun number of characters to a single line of the raw output
file specified by $EST FILE=. where NUMTEXT is number of charac-
ters needed to represent a number and its delimiter. For exam-
ple, FORMAT=,1PE12.5 takes up NUMTEXT=13 characters.
LSFORM=2048
LSFORM is the character length of FORMAT TFORMATL,RFORMATL, per-
taining to the full length of LFORMAT, RFORMAT for the $TABLE
record.
MAXRECID=200
Maximum number of records in any individual record. For use by
PREDPP. Value may be over-ridden by user via $SIZES record
PC=30
MAX. NO. OF COMPARTMENTS MAXIMUM IS 99. Value may be over-ridden
by user via $SIZES record
PCT=30
MAX. NO. OF MODEL EVENT TIMES. Value may be over-ridden by user
via $SIZES record
PCT_BIG=10000
MAX. NO. OF MODEL EVENT TIMES THAT NMTRAN CAN PROCESS.^M ! PG:
SIZE OF GG; MAX. NO. OF BASIC+ADDITIONAL PK PARAMS.^M ! (MAX-
IMUM IS PCT+99)^M
PIR=700
SIZE OF COMPACT DA/DP/DT ARRAYS. Value may be over-ridden by
user via $SIZES record
PD=50
CHANGED TO INCREASE DATA ITEMS PER DATA RECORD FROM 20 TO 50 IT
IS ALSO SIZE OF VDATREC DATA ARRAY. THIS IS DONE TO SEPARATE VDA-
TREC AND VRESWRES VARIABLES/ Dynamically sized, or set by user
via $SIZES record.
MAXIC=90
MAXIC: MAXIMUM NUMBER OF ACTIVE INFUSIONS FOR PREDPP. Value may
be over-ridden by user via $SIZES record
PDT=500
MAXIMUM NUMBER OF TABLE ITEMS/PRED-DEFINED ITEMS. Value may be
over-ridden by user via $SIZES record
PAL=50
NO. OF ADDITIONAL AND LAGGED DOSES. Value may be over-ridden by
user via $SIZES record
MAXFCN=1000000
MAX. NO. OF CALLS IN GENERAL NON-LINEAR MODELS IMAX IN MODULE
PRCOM_INT OVERRIDES. Value may be over-ridden by user via $SIZES
record
STIELTJ_SIZE=101
The next four are for internal use, pertaining to various addi-
tional weighted residual diagnostics
MAXXNAME=40
MAXVRESWRES=39
MAXVRESN=9
MXNAME=40
DIMTMP=500
RELATED TO THE NUMBER OF USER-DEFINED VARIABLES. Value may be
over-ridden by user via $SIZES record
DIMCNS=500
RELATED TO THE TOTAL NUMBER OF CONSTANTS. Value may be over-rid-
den by user via $SIZES record
DIMNEW=1000
RELATED TO THE TOTAL NUMBER OF INTERMEDIATE VARIABLES. Value may
be over-ridden by user via $SIZES record
DIMQ=99999
ARRAY SIZE FOR LOGICAL CONDITIONS
FL=41
LOGICAL UNIT NUMBER FOR FLIB
DIMVRB=1000
MAX. NO. OF LINES OF VERBATIM CODE
PL=10
MAXIMUM DEPTH OF NESTED IF STATEMENTS
NFUNCX=100
MAXIMUM NUMBER OF USER FUNCTIONS.
NVECX=100
MAXIMUM NUMBER OF USER VECTORS.
MAXOTHER=1000
Maximum number of filenames listed on $SUBROUTINE OTHER=filename
SD=30
LENGTH OF DATA LABEL
FSD=67000
LENGTH OF CONTROL STREAM FILE STRING (ALSO, MULTIPLE LINES CON-
CATENATED WITH & MAY NOT EXCEED FSD)
FSD1=67001
LENGTH OF CONTROL STREAM FILE STRING
SCO=30
STRING LENGTH OF NUMBER IN $THETA, $OMEGA, $SGIGMA RECORDS.
SDF=24
LENGTH OF DATA ITEM
NFSIZES=48
NUMBER OF ITEMS LISTED IN FSIZES FILE
NPRSIZES=12
NUMBER OF PREDPP ITEMS IN PRSIZES.F90
CONSTANTS FOR Monte Carlo, EM methods
MAX_EXTRA=20
Numer of $EST statements allowed per problem
NPOPMIXMAX=10
Now dynamically sized to MAXIMUM NUMBER OF SUB-POPULATIONS FOR
MIXTURE MODELS MMX. Or, set by user via $SIZES record
MAXOMEG=70
Now dynamically sizes to LVR, OR MAXIMUM OMEGA DIMENSION ETAS.
Or, set by user via $SIZES record (but should be left alone)
MAXPTHETA=90
Now dynamically sized to LTH, MAXIMUM NUMBER OF THETA, PLUS LOWER
TRIANGLE OF SIGMA. THUS, IF NUMBER OF THETAS IS N, AND DIMENSION
OF SIGMAS IS M, THEN NEED MAXPTHETA=N + M*(M+1)/2. OR, may be
set by user via $SIZES record (but should be left alone).
MAXITER=210
Maximum number of previous iterations to incorporate into Monte
Carlo convergence tests Effective CITER is <=MAXITER
ISAMPLEMAX=10
FOR SAEM METHOD, EFFECTIVE ISAMPLE<=ISAMPLEMAX
MAXSIDS=100
MAXIMUM NUMER OF SUPER ID ITEMS IN DATA SET
MAXSIDL=0
MAXIMUM LEVEL OF SUPER IDS. MAXSIDL=0 MEANS NO SUPER IDS.
Default 0, until $LEVEL is used, in which case it will be dynami-
cally sized.
MAXFTEXT=100
Maximum of PRDERR message lines
PNM_MAXNODES=100
MAXIMUM NUMBER OF PARALLELIZATION NODES
PNM_BUFFER_SIZE=100000
INTERNAL BUFFER SIZE, FOR EFFICIENT PACKAGING AND SENDING BETWEEN
PROCESSES
LEV='7.4.0 '
The LEV constant in MODULE VERSION should not be changed by the
user.
REFERENCES: Guide III Section V.3.0
REFERENCES: Guide Section Introduction_7
Go to main index.
Created by nmhelp2html v. 1.0 written by Niclas Jonsson (Modified by AJB 5/2006,11/2007,10/2012)