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| $ESTIMATION RECORD OPTIONS |
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MEANING: Instructions for the NONMEM Estimation Step
CONTEXT: NM-TRAN Control Record
List of $ESTIMATION Record Options and Their Relevance to Various
Methods
Classical methods are the First order method (METHOD=0 or METHOD=FO),
the Conditional method (METHOD=1 or METHOD=FOCE) and the Hybrid method
(METHOD=HYBRID). All other methods are EM (Expectation-Maximization)
/ Bayesian methods and are new to NONMEM 7.
Option Classical ITS DIRECT IMP IMPMAP SAEM BAYES NUTS
-2LL X X X X X X X X
ATOL + X X X X X X X X
AUTO X X X X X X X
CALPHA X X X X X X X
CENTERING X
CINTERVAL X X X X X X X
CITER/CNSAMP X X X X X X X
CONDITIONAL X X X X X X X X
CONSTRAIN X X X X X X X
CTYPE (CTYPE 4) X X X X X X X
DERCONT X X X X
DF X X
DFS(CHAIN only)
EONLY X X X X
ETABARCHECK X
ETADER X X X X
ETASAMPLES X X X
ETASTYPE X X X X X X
FILE X X X X X X X X
FNLETA X X X X X X X X
Option Classical ITS DIRECT IMP IMPMAP SAEM BAYES NUTS
FORMAT/DELIM X X X X X X X X
FPARAFILE X X X X X X X X
GRD X X X X X X X
GRDQ X X
GRID(Stieltjes) X
HYBRID X
IACCEPT X X X X X
IACCEPTL X X
INTERACTION X X X X X X X X
IKAPPA X
ISAMPEND X X X X
ISAMPLE X X X
ISAMPLE_M1 X X X
ISAMPLE_M1A X X X
ISAMPLE_M1B X X X
ISAMPLE_M2 X X X
ISAMPLE_M3 X X X
ISCALE_MAX X X X X X
ISCALE_MIN X X X X X
Option Classical ITS DIRECT IMP IMPMAP SAEM BAYES NUTS
KAPPA X
KNUTHSUMOFF X X X X X X X X
LAPLACE X X * * X * * *
LEVWT($LEVEL) X X X X X X X X
LIKE X X X X X X X X
LNTWOPI X X X X X X X X
MADAPT X
MAPCOV X X
MAPINTER X X
MAPITER X X
MASSRESET *** X
MAXEVAL X
MCETA X X X X
MSFO X X X X X X X X
MUM X X X X X X X
NBURN X X X
NITER/NSAMPLE X X X X X X X
NOABORT X X X X X X X X
NOCOV** X X X X X X X
Option Classical ITS DIRECT IMP IMPMAP SAEM BAYES NUTS
NOHABORT X X X X X X X X
NOLABEL X X X X X X X X
NONINFETA X
NOOMEGABOUNDTEST X
NOPRIOR X X X X X X X X
NOSIGMABOUNDTEST X
NOSUB X X X X X X X X
NOTHETABOUNDTEST X
NOTITLE X X X X X X X X
NSIG/SIGDIGITS X X
NUMDER X X X X X X X X
NUMERICAL X X * * X * * *
Option Classical ITS DIRECT IMP IMPMAP SAEM BAYES NUTS
NUTS_BASE X
NUTS_DELTA X
NUTS_EPARAM *** X
NUTS_GAMMA X
NUTS_INIT X
NUTS_MASS *** X
NUTS_MAXDEPTH X
NUTS_OPARAM *** X
NUTS_REG *** X
NUTS_SPARAM *** X
NUTS_STEPINTER X
NUTS_STEPITER X
NUTS_TERM X
NUTS_TEST X
NUTS_TRANSFORM X
OACCEPT X X
OLKJDF X
OLNTWOPI X X X
OMEGABOUNDTEST X
Option Classical ITS DIRECT IMP IMPMAP SAEM BAYES NUTS
OMITTED X X X X X X X X
OPTMAP X X X X
ORDER X X X X X X X X
OSAMPLE_M1 X X
OSAMPLE_M2 X X
OVARF X
PACCEPT X X
PARAFILE X X X X X X X X
PARAFPRINT X X X X X X X X
PHITYPE X X X X X X X
POSTHOC X X X X X X X X
PREDICTION X X X X X X X X
PRINT X X X X X X X X
PRIORC X X X X X X X X
PSAMPLE_M1 X X
PSAMPLE_M2 X X
PSAMPLE_M3 X X
PSCALE_MAX X X
PSCALE_MIN X X
Option Classical ITS DIRECT IMP IMPMAP SAEM BAYES NUTS
RANMETHOD=nSmP X X X X X X
REPEAT X
REPEAT1 X
REPEAT2 X
SADDLE_HESS X
SADDLE_RESET X
SEED X X X X X X
SIGL X X X X X X
SIGLO X X X X
SIGMABOUNDTEST X
SLKJDF X
SLOW/NOSLOW/FAST X X * * X * * *
SORT X
STDOBJ X X
STIELTJES X
SVARF X
THETABOUNDTEST X
THIN X X
TTDF X
ZERO X
Option Classical ITS DIRECT IMP IMPMAP SAEM BAYES NUTS
+ ADVAN9,ADVAN13,ADVAN14,ADVAN15
*May be needed to suppress error messages from NMTRAN or NONMEM.
**When last estimation step
***In prep for NUTS
(See $ESTIMATION).
REFERENCES: Guide Introduction_7
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